Identification of the Cellular Effects of Sofosbuvir and Amiodarone using hiPSC-Derived CardiomyocytesWednesday, 6 April 2016 at 11:45 Add to Calendar ▼2016-04-06 11:45:002016-04-06 12:45:00Europe/LondonIdentification of the Cellular Effects of Sofosbuvir and Amiodarone using hiPSC-Derived CardiomyocytesStem Cells in Drug Discovery 2016 in Cambridge, UKCambridge, UKSELECTBIOenquiries@selectbiosciences.com Combined administration of sofosbuvir and amiodarone may lead to bradycardia in the clinic. We investigated their interaction on the cellular level using human stem cell derived cardiomyocytes. Our results indicate compromised excitation-contraction coupling mediated by impaired calcium handling. |