Dr. Veerle Reumers obtained her Master’s and Ph.D. degree in biomedical sciences from the University of Leuven. Before joining imec, she performed her postdoctoral research on molecular imaging techniques in neurosciences at Harvard Medical School. In the Life Sciences department at imec she explored different applications of imec technology blocks in the field of cell biology with a main focus on lens-free imaging and multi-electrode array electrophysiology. As R&D team leader she was leading research and development projects, ranging from public funded academic collaborations to industry driven bilateral projects. Currently she is R&D manager in the imec Florida office, initiating new collaborations and research projects in imaging and space health.
Electrophysiology Monitoring and Other Mechanistic Studies Aboard Microgravity and-or Spaceflight
Tuesday, 8 November 2022 at 14:50
Add to Calendar ▼2022-11-08 14:50:002022-11-08 15:50:00Europe/LondonElectrophysiology Monitoring and Other Mechanistic Studies Aboard Microgravity and-or SpaceflightThe Space Summit 2022 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
The use of microfluidic tissue-on-a-chip devices in conjunction with electrophysiology (EPHYS) techniques has become prominent in recent years to study cell-cell interactions critical to the understanding of cellular function in extreme environments, including spaceflight and microgravity. Current techniques are confined to invasive whole-cell recording at intermittent time points during spaceflight, limiting data acquisition and overall reduced insight on cell behavior. Currently, there exists no validated technology that offers continuous EPHYS recording and monitoring in physiological systems exposed to microgravity. In collaboration with imec and SpaceTango, we have developed an enclosed, automated research platform that enables continuous monitoring of electrically active human cell cultures during spaceflight. The Neuropixels probe system (imec) will be integrated for the first time within an engineered in-vitro neuronal tissue-on-a-chip model that facilitates the EPHYS recording of cells in response to extracellular electrical activity in the assembled neuronal tissue platform. Our goal is to study the EPHYS recordings and understand how exposure to microgravity affects cellular interaction within human tissue-on-a-chip systems in comparison to systems maintained under Earth’s gravity. Results may be useful for dissecting the complexity of signals obtained from other tissue systems, such as cardiac or gastrointestinal, when exposed to microgravity. This study will yield valuable knowledge regarding physiological changes in human tissue-on-a-chip models due to spaceflight, as well as validate the use of this type of platform for more advanced research critical in potential human endeavours to space.
Add to Calendar ▼2022-11-07 00:00:002022-11-08 00:00:00Europe/LondonThe Space Summit 2022The Space Summit 2022 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2022-11-08 14:50:002022-11-08 15:50:00Europe/LondonElectrophysiology Monitoring and Other Mechanistic Studies Aboard Microgravity and-or SpaceflightThe Space Summit 2022 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
