The Role of Defence and Adaptation in Drug-Mediated Liver ToxicityTuesday, 13 March 2012 at 11:15 Add to Calendar ▼2012-03-13 11:15:002012-03-13 12:15:00Europe/LondonThe Role of Defence and Adaptation in Drug-Mediated Liver ToxicityADME and Predictive Toxicology Europe in Munich, GermanyMunich, GermanySELECTBIOenquiries@selectbiosciences.com Chemical stress is a potentially deleterious state induced by exposure of cells to non-physiological levels of chemically reactive species (CRS) and it can play a role in off-target adverse drug reactions (ADRs). Whilst we are beginning to understand some of the key events that influence how the liver adapts to exposure to chemicals, we are still some distance from understanding how this actually pertains to Man. This talk will review the field and highlight key recent developments and the most significant challenges to our understanding as to whether defence and adaptation influences individual susceptibility. |