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SELECTBIO Conferences ADME & Predictive Toxicology

Maria Miteva's Biography



Maria Miteva, Research Director/Group Leader, University Paris Diderot

Dr. Maria A. Miteva received PhD in bioinformatics and biophysical chemistry in 2000 from the Bulgarian Academy of Science, the Institute of Organic Chemistry. Dr. Miteva has research experience in biophysics, chemoinformatics, bioinformatics, in silico drug design and ADME-Tox predictions. She has been working as a researcher in Bulgaria, Sweden and France. Currently she is a Research Director and leading the team “ PPI & ADMET in silico” belonging to Paris Diderot University and the French institute of health research Inserm, Unit 973. Her team is working on virtual screening and drug design with a focus on protein-protein interaction modulators and ADME-Tox predictions. She published over 75 research articles and she edited a book “In silico lead discovery “ (Bentham Science Publishers). Dr. Miteva is responsible for a teaching module of about 100 hours per year for the international master programme “in silico Drug Design” at the University Paris Diderot. Currently she is an appointed member of the editorial board of 6 international journals in the field of bioinformatics and drug design, and Associated Editor for BMC Toxicology & Pharmacology.

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In Silico Structure-based Approach for ADMET Prediction: Mechanistic Insights from Probing Small Molecule Binding to Metabolizing Enzymes

Wednesday, 19 February 2014 at 17:00

Add to Calendar ▼2014-02-19 17:00:002014-02-19 18:00:00Europe/LondonIn Silico Structure-based Approach for ADMET Prediction: Mechanistic Insights from Probing Small Molecule Binding to Metabolizing EnzymesADME and Predictive Toxicology in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com

Computational protein structure-based approach was used to gain mechanistic insights from probing drug-like molecules binding to the metabolizing enzymes cytochrome P450 2D6 and sulfotransferases. The results suggest that structure-based ADMET approach is useful for prioritizing compounds and may be used to go 'beyond QSAR profiling' in order to assist decision-making in drug discovery.


Add to Calendar ▼2014-02-18 00:00:002014-02-19 00:00:00Europe/LondonADME and Predictive ToxicologyADME and Predictive Toxicology in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com