Shopping Cart (0)
My Account

Shopping Cart
SELECTBIO Conferences ADME & Predictive Toxicology

Ismael Zamora's Biography



Ismael Zamora, Associate Professor, Lead Molecular Design SL

Ismael Zamora is associate professor at Prompeu Fabra University in Barcelona and CEO at Lead Molecular Design, a company dedicated to research in software for drug metabolism, like MetaSite, MassMetaSite and WebMetabase. He received the PhD in organic Synthesis in 1998 at the Institut Quimic de Sarria in Barcelona and a post-doctoral stage at Professor Cruciani lab in University of Perugia during 1999 where started to model absorption properties of compounds across the gastrointestinal tract and the blood-brain barrier. After that period he joined AstraZeneca in Möndal first as a postdoctoral fellow and later as scientific researcher as modeller in the DMPK department until 2001. He received the 11th Corwin Hansch award in 2010 by the CHemoinformatics and QSAR society for his tireless work together with the ADMET community to integrate modeling & QSAR technologies into drug discovery.

Ismael Zamora Image

Metabolism: An Integrative View of in-vitro/in-silico Approaches to Design New Compounds

Tuesday, 18 February 2014 at 15:15

Add to Calendar ▼2014-02-18 15:15:002014-02-18 16:15:00Europe/LondonMetabolism: An Integrative View of in-vitro/in-silico Approaches to Design New CompoundsADME and Predictive Toxicology in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com

There are several aspects of xenobiotic metabolism that are relevant for Drug Discovery, moving from clearance of the compound to the drug-drug interaction produced by reactive metabolites or inhibition of metabolic enzymes. All these factors can be studied in in-vitro systems, that typically yield a number (i.e. IC50 when measuring inhibition properties or Clint when measuring clearance properties). In this presentation we will show an innovative approach that mixes in-vitro results from High Resolution Mass Spec with in-silico tools to provide not only a number but an hypothesis for the cause of the metabolic interaction.


Add to Calendar ▼2014-02-18 00:00:002014-02-19 00:00:00Europe/LondonADME and Predictive ToxicologyADME and Predictive Toxicology in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com