CANCELLED DUE TO ILL HEALTH - Exploratory Toxicology Integrated in the Drug Discovery ProcessWednesday, 19 February 2014 at 11:30  Add to Calendar ▼2014-02-19 11:30:002014-02-19 12:30:00Europe/LondonCANCELLED DUE TO ILL HEALTH - Exploratory Toxicology Integrated in the Drug Discovery ProcessADME and Predictive Toxicology in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.comToxicity and clinical safety issues have been identified as major reasons for failure of drug development programs. Moving predictive toxicology studies into an earlier phase of the R&D value chain (fail early, fail cheap) prevents drug candidates with a potential human safety risk from entering clinical development. However, that does not automatically secure the identification of drug candidates without that risk. Therefore, toxicology has to be fully integrated into the drug discovery process. A successful ‘integrated tox’ strategy should include the safety assessment of novel drug targets (as part of target validation), the selection of chemical series without inherent safety issues (as part of the hit-to-lead process), designing out risk factors (as part of lead optimization) and a broader toxicological profiling of potential drug candidates (as part of development candidate selection). The aim is to avoid risk as well as steer away from potential liabilities during drug discovery. I will discuss our exploratory toxicology strategy and discuss some examples of compound testing paradigms using early in vitro, ex vivo and in vivo assays and models to assess safety risks. |
Add to Calendar ▼2014-02-18 00:00:002014-02-19 00:00:00Europe/LondonADME and Predictive ToxicologyADME and Predictive Toxicology in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com
