Morphological and Functional Characterization of Cell-Based BBB Penetration ModelsMonday, 28 March 2011 at 11:45 Add to Calendar ▼2011-03-28 11:45:002011-03-28 12:45:00Europe/LondonMorphological and Functional Characterization of Cell-Based BBB Penetration ModelsADMET Europe in MunichMunichSELECTBIOenquiries@selectbiosciences.com Cell-based models, like the triple co-culture model using brain derived cells, and models using MDCKII-MDRI, Caco-2 or the recently introduced VB-Caco-2 cultures can be used as cell-based tools to predict brain penetration of new drug candidates. This talk compares the critical morphological and functional features of cell-based models, using in-house generated data, which contribute towards differing/similar permeability functions. |