Using Continuous Culture Metabolomics to Study Environmental Effects in Pseudomonas aeruginosaWednesday, 9 November 2011 at 14:15  Add to Calendar ▼2011-11-09 14:15:002011-11-09 15:15:00Europe/LondonUsing Continuous Culture Metabolomics to Study Environmental Effects in Pseudomonas aeruginosa Advances in Metabolic Profiling in Dublin, IrelandDublin, IrelandSELECTBIOenquiries@selectbiosciences.comThe use of bacterial continuous culture (chemostat) was validated as a stable and controllable method of monitoring the effect of environmental conditions on the growth and metabolism of Pseudomonas aeruginosa. Global metabolomics analysis and targeted pathway profiling methods using LC-MS were established to monitor intra- and extracellular metabolites. P. aeruginosa was shown to adapt its production of pivotal signalling molecules according to its environment, resulting in modulation of central metabolism and virulence factor production. This observation has clinical relevance to P. aeruginosa behaviour in biofilm formation and in cystic fibrosis patients |
Add to Calendar ▼2011-11-08 00:00:002011-11-09 00:00:00Europe/LondonAdvances in Metabolic ProfilingAdvances in Metabolic Profiling in Dublin, IrelandDublin, IrelandSELECTBIOenquiries@selectbiosciences.com
