Anita Maguire's Biography

Anita Maguire, Professor of Pharmaceutical Chemistry, University College Cork

Anita is a graduate of UCC (BSc 1985, PhD 1989). Following postdoctoral research in Namur, Belgium then in Exeter, UK, Anita returned to UCC in 1991 to establish a research team in synthetic organic chemistry and has played a strategic role at the interface with the pharmaceutical industry. She is a Co-PI in the national SFI Centre SSPC. She was elected as a Member of the Royal Irish Academy in 2014 and appointed RIA Vice President in 2019. She was an Adjunct Professor in the University of Bergen, 2011-16. She was VP Research & Innovation in UCC 2011-21. Throughout her career she has been actively engaged nationally in strategic R&I policy development including as a member of the Advisory Science Council. Since 2015 she is the inaugural Chair of the National Forum on Research Integrity, leading national policy development and implementation in this area.

Enhancing the Synthetic Utility of alpha-Diazocarbonyl Compounds Through Use of Continuous Flow Technology

Thursday, 17 March 2022 at 11:30

Add to Calendar ▼2022-03-17 11:30:002022-03-17 12:30:00Europe/LondonEnhancing the Synthetic Utility of alpha-Diazocarbonyl Compounds Through Use of Continuous Flow TechnologyInnovations in API Manufacture 2022 in BostonBostonSELECTBIOenquiries@selectbiosciences.com

While alpha-diazocarbonyl compounds are extremely versatile intermediates in organic synthesis, their use at scale is limited by safety concerns, in particular in relation to potentially hazardous precursors such as sulfonyl azides or diazoalkanes. Recent results from the team will be presented showing that sulfonyl azides can be generated in flow and used directly in diazo transfer to form a wide range of alpha-diazocarbonyl compounds. Furthermore, the successful telescoping of these steps with subsequent enantioselective transition metal catalyzed reactions has been demonstrated. Thus, the synthetic potential of alpha-diazocarbonyl compounds can be accessed without isolating or handling either the sulfonyl azide or the alpha-diazocarbonyl compound. Five distinct protocols for diazo transfer in continuous flow have been developed, ensuring broad applicability across a range of substrates.

Add to Calendar ▼2022-03-17 00:00:002022-03-18 00:00:00Europe/LondonInnovations in API Manufacture 2022Innovations in API Manufacture 2022 in BostonBostonSELECTBIOenquiries@selectbiosciences.com

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