COLD-PCR Enhances High Resolution Melting and Next Generation Technologies for Sensitive Detection of Low-Level Cancer MutationsThursday, 19 April 2012 at 16:30 Add to Calendar ▼2012-04-19 16:30:002012-04-19 17:30:00Europe/LondonCOLD-PCR Enhances High Resolution Melting and Next Generation Technologies for Sensitive Detection of Low-Level Cancer MutationsSELECTBIOenquiries@selectbiosciences.com Utilizing the clinical and diagnostic potential of low-abundance mutations present within wild-type DNA is vital for several fields, including cancer biomarker development, prenatal diagnosis, and infectious diseases. We show that the combination of enhanced forms of real-time COLD-PCR with high resolution melting (HRM) as well as with next generation sequencing broadens the application of these powerful technologies for detecting low-level mutations in circulating DNA, circulating cells, FFPE, sputum or other bodily fluids, tumor margins and stromal cells. |