Alexander Bishop's Biography

Alexander Bishop, Assistant Professor, University of Texas Health Science Center

Dr. Bishop obtained his D.Phil at Oxford University using yeast models to measure homologous recombination. His first postdoc at Harvard examined the relationship of DNA damage response gene and homologous recombination using mouse models. A second postdoc in Harvard set out to identify new genes and pathways involved in DNA damage response and survival using RNAi genomic screening with Drosophila cells. Much of the work resulting from these screens required developing novel methodologies, bioinformatics tools and databases. From his studies he developed a more comprehensive understanding of damage response. To extend these studies and to facilitate the application of the knowledge acquired from the RNAi screening he has recently been using gene expression (microarrays and RNA sequencing) to further explore damage response and how they are affected in various cancers.