Dr. Fabien Guillemot is the founder of Poietis, a bioprinting company which harnesses the Laser-Assisted Bioprinting technology to fabricate complex and customized tissues for regenerative medicine and pharmaceutical applications. He obtained his PhD in Materials Science in 2000 from the National Institute for Applied Sciences (Rennes, France). He was appointed in 2005 Senior Researcher at the National Institute for Health and Medical Research (INSERM, France). He initiated and led till 2014 the project Tissue Engineering Assisted by Laser (TEAL) which aimed at developing laser-assisted technologies for fabricating artificial tissues into which cells are organized into defined 3D micro-environments. Dr. Guillemot is the author of more than 50 articles in peer-reviewed journals and about 40 invited conferences.
3D Multimodal Bioprinter Capable of Multiscale Deposition to Deal with Tissue Complexity
Friday, 17 March 2017 at 09:00
Add to Calendar ▼2017-03-17 09:00:002017-03-17 10:00:00Europe/London3D Multimodal Bioprinter Capable of Multiscale Deposition to Deal with Tissue ComplexitySELECTBIOenquiries@selectbiosciences.com
Dealing with tissue complexity and reproducing the functional anisotropy of human tissues remain a puzzling challenge for tissue engineers. Emergence of the biological functions results from dynamic interactions between cells, and with extracellular matrix. Experimental data showing that cell fate (migration, polarization, proliferation…) is triggered by biochemical and/or mechanical cues arising from cell micro-environment suggests that tissue formation obeys to short range orders without reference to a macroscopic or global pattern. In that context, the winning tissue engineering strategy might rely on guiding tissue morphogenesis from the cell to the tissue level. From a technological point of view, the Laser-Assisted Bioprinting (LAB) technology has emerged as an alternative method to inkjet and bioextrusion methods, thereby overcoming some of their limitations (namely clogging of print heads or capillaries) to pattern living cells and biomaterials with a micron-scale resolution and high cell viability. LAB applications has been limited so far to biofabrication of thin constructs. In this work, we present an original 3D multimodal and modular bioprinter which combines LAB with microvalve bioprinting. Thanks to this system, cells can be printed at cell resolution using LAB while biomaterials are printed with a coarser resolution (100 µm) using microvalve bioprinting. Interestingly, we show that 1 mm thick 3D constructs can be printed with different biomaterial layer thicknesses (eg made of collagen, agarose) and with multiple cell micropatterns across tissue constructs. In conclusion, combining technologies featured by different resolution opens new horizons for controlling micro and macro organization of tissue components, and hence for guiding cellular morphogenesis within thick 3D tissues.
Add to Calendar ▼2017-03-16 00:00:002017-03-17 00:00:00Europe/LondonBioMEMS, Microfluidics and Biofabrication: Technologies and ApplicationsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2017-03-17 09:00:002017-03-17 10:00:00Europe/London3D Multimodal Bioprinter Capable of Multiscale Deposition to Deal with Tissue ComplexitySELECTBIOenquiries@selectbiosciences.com
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