Amy J. Wagoner Johnson,
Associate Professor, Department of Mechanical Science and Engineering,
University of Illinois at Urbana-Champaign
Professor Wagoner Johnson is an Associate Professor in the Department of Mechanical Science and Engineering (MechSE) at the University of Illinois at Urbana-Champaign and a current Chair of Excellence with the NanoScience Foundation (Grenoble, France). Her research focuses on biomaterials and biomechanics, including soft tissues and synthetic polymers, and microstructural cues in CaP-based materials for bone regeneration. She received her BS in Materials Science and Engineering from The Ohio State University in 1996, and PhD in Engineering from Brown University in 2002 with major in materials science and minors in solid mechanics and applied math. She joined University of Illinois in 2001 as research faculty, began as an Assistant Professor in 2005, and was promoted to Associate Professor in 2012. She received the Arnold O. Beckman Research Award at the University of Illinois for “projects of special distinction” in 2011 and the Alice Jee Memorial Award in 2008. She has received a number of awards for advising at Illinois including the Campus Award for Guiding Undergraduate Research in 2013, and the Engineering Council Award for Excellence in Advising in 2009 and 2012. She is currently a part-time faculty member of the Beckman Institute for Advanced Science and Technology, and has affiliations with the Department of Bioengineering, and Institute for Genomic Biology, where she is a Core Member of the Regenerative Biology and Tissue Engineering Theme.
Capillary Forces and Bone Regeneration in Bone Scaffolds
Friday, 17 March 2017 at 11:30
Add to Calendar ▼2017-03-17 11:30:002017-03-17 12:30:00Europe/LondonCapillary Forces and Bone Regeneration in Bone ScaffoldsSELECTBIOenquiries@selectbiosciences.com
More than 1.5 million people undergo bone graft procedures annually in
the US to repair defects that will not heal spontaneously. These defects
severely decrease quality of life and are an economic burden to those
affected and to the health care system. The already considerable demand
is growing rapidly as the population ages and life expectancy increases.
The biggest technical and scientific challenge to treating these
defects is in achieving complete osteointegration. There are promising
approaches that combine scaffolds with exogenous cells and growth
factors; however, these approaches are complex, expensive, and are still
often considered to be too risky to the patient. Our approach is to use
capillary action to impregnate biphasic calcium phosphate (BCP)
scaffolds that have macro and microporosity, with cells at the time of
implantation. Three groups of samples, DRY, WET, and samples without
micropores (NMP), were implanted for 3 weeks and then imaged using
microcomputed tomography and assessed by histology. WET samples had
microporosity, but were infiltrated with PBS prior to implantation.
After three weeks, the average bone volume fraction was the same for DRY
versus WET, and both were greater than NMP. However, the distribution
of bone and the depth of bone growth was significantly enhanced for DRY
samples compared to WET and NMP. The results have important implications
in scaffold design and use of this mechanism will help to address the
challenge of incomplete osteointegration in scaffold-based bone repair.
Further, it will do so without the use of growth factors or exogenous
cells.
Add to Calendar ▼2017-03-16 00:00:002017-03-17 00:00:00Europe/LondonBioMEMS, Microfluidics and Biofabrication: Technologies and ApplicationsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2017-03-17 11:30:002017-03-17 12:30:00Europe/LondonCapillary Forces and Bone Regeneration in Bone ScaffoldsSELECTBIOenquiries@selectbiosciences.com
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