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SELECTBIO Conferences Biofabrication & Biomanufacturing 2022

Nathan Crook's Biography

Nathan Crook, Assistant Professor, North Carolina State University

Dr. Crook received his B.S. in Chemical Engineering from the California Institute of Technology in 2009, and his Ph.D. in Chemical Engineering from the University of Texas at Austin in 2014, studying under Dr. Hal Alper. He pursued postdoctoral studies in Pathology and Immunology at Washington University in Saint Louis School Medicine from 2014-2017 in the lab of Dr. Gautam Dantas. Dr. Crook joined the department of Chemical and Biomolecular Engineering at NCSU in January 2018, and his lab focuses on how to engineer microbial communities.

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Establishing Saccharomyces Boulardii as an In-Gut Biomanufacturing Platform

Tuesday, 22 March 2022 at 13:00

Add to Calendar ▼2022-03-22 13:00:002022-03-22 14:00:00Europe/LondonEstablishing Saccharomyces Boulardii as an In-Gut Biomanufacturing PlatformBiofabrication and Biomanufacturing 2022 in

Saccharomyces boulardii is a widely used yeast probiotic, demonstrating effectiveness against various gastrointestinal disorders. S. boulardii is therefore a promising chassis for development of personalized engineered probiotic medicines. In this talk, I will discuss our lab’s recent progress in optimizing both small molecule and peptide biosynthesis in this strain, as well as our efforts to enhance S. boulardii’s in vivo residence time.  Last, I will discuss some new work from our lab focusing on the development of gut- and small-molecule inducible promoters for this organism. Taken together, this work establishes S. boulardii as a genetically tractable commensal fungus and demonstrates the delivery of therapeutics during colonization.

Add to Calendar ▼2022-03-21 00:00:002022-03-22 00:00:00Europe/LondonBiofabrication and Biomanufacturing 2022Biofabrication and Biomanufacturing 2022 in