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A "Human-on-a-Chip" platform - Aiming for a Paradigm Shift in Substance TestingWednesday, 8 July 2015 at 14:30  Add to Calendar ▼2015-07-08 14:30:002015-07-08 15:30:00Europe/LondonA "Human-on-a-Chip" platform - Aiming for a Paradigm Shift in Substance TestingSELECTBIOenquiries@selectbiosciences.comStrategies to develop “human-on-a-chip” platforms are applying micro-physiological systems towards the in vitro combination of miniaturized human organ equivalents into functional human mini-organisms, which aim to replace systemic toxicity testing and efficacy assessment of new drug candidates in animals. We have developed a universal multi-organ-chip platform for long-term culture of human 3D organ equivalents interconnected within a common capillary microfluidic network, mimicking physiological blood flow. A standard microscopic slide format has been selected for the microfluidic multi-organ-chips. The human organs are scaled down by a factor of 1:100000. Proof of concept combining miniaturized human liver and skin equivalents at steady culture conditions over 28 days was achieved. Subsequently, repeated dose substance test assays with co-cultures of human skin interconnected with dendritic cells and human liver in combination with neuronal spheroids have been qualified. Finally, in addition to the two organ-chip assays, a four-organ-chip combining human intestine, liver, skin and kidney equivalents into a functional ADMET test assay has been established. |
Add to Calendar ▼2015-07-08 00:00:002015-07-09 00:00:00Europe/LondonOrgan-on-a-Chip ConferenceSELECTBIOenquiries@selectbiosciences.com
