Elena Castellanos-Rizaldos's Biography

Elena Castellanos-Rizaldos, Instructor in Radiation Oncology, Dana-Farber Cancer Institute/Harvard Medical School

Dr. Castellanos-Rizaldos is an Instructor at the Department of Radiation Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, USA. She has a background in Microbiology, with focus on development of molecular methods to detect mycobacterial species. Her PhD work has been recognized with the prestigious SYVA award, Johne’s Disease Integrated Program (JDIP) Award and PhD Excellence Award. Her research interests include the development of novel DNA technologies for molecular diagnostics with application in Oncology. Working at the laboratory of Dr. Makrigiorgos she developed new PCR-based techniques such as Temperature-tolerant-COLD-PCR, work recognized with the Young Investigator Award at the Association for Molecular Pathology 2011 Meeting.

Implementation of COLD-digital-PCR for Detecting Low Level Mutations in Circulating DNA

Tuesday, 25 March 2014 at 17:00

Add to Calendar ▼2014-03-25 17:00:002014-03-25 18:00:00Europe/LondonImplementation of COLD-digital-PCR for Detecting Low Level Mutations in Circulating DNACirculating Biomarkers 2014 in Boston, Massachusetts, USABoston, Massachusetts, USASELECTBIOenquiries@selectbiosciences.com

CO-amplification at Low Denaturation Temperature- PCR (PCR) amplifies preferentially rare mutations buried within an excess of wild type DNA. We have adapted COLD-PCR into emulsion-digital PCR (COLD-digital PCR) format and demonstrated highly enhanced sensitivity. We apply COLD-digital PCR to detection of T790M mutations present in tumor circulating DNA obtained from patients with lung adenocarcinoma. COLD-digital PCR improved the discrimination of T790M mutations present at a very low level, facilitating disease monitoring and selection of appropriate therapy regimens.

Add to Calendar ▼2014-03-24 00:00:002014-03-25 00:00:00Europe/LondonCirculating Biomarkers 2014Circulating Biomarkers 2014 in Boston, Massachusetts, USABoston, Massachusetts, USASELECTBIOenquiries@selectbiosciences.com

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