Ionita Ghiran,
Assistant Professor of Medicine,
Beth Israel Deaconess Medical Center
Dr. Ghiran received his MD from the “Iuliu Hatieganu” Medical School University, Cluj Napoca in Romania, before completing his postdoctoral training at Beth Israel Deaconess Medical Center in Boston where he is currently an Assistant Professor in the Department of Medicine at the Beth Israel Deaconess Medical Center (BIDMC)/Harvard Medical School in Boston, MA. Dr. Ghiran’s focus in on understanding the regulation of extracellular vesicles originating from red cells, and the role of the red cell-derived miRNAs in normal and pathological conditions. Recently, Dr. Ghiran and his colleagues described the significant impact of the circadian rhythm in the number and protein composition of circulating blood extracellular vesicles, as well as in the origin and quantity of various extracellular miRNAs species.
The Role of Terminal Complement Components in Plasma miRNAs Composition
Tuesday, 22 March 2016 at 10:00
Add to Calendar ▼2016-03-22 10:00:002016-03-22 11:00:00Europe/LondonThe Role of Terminal Complement Components in Plasma miRNAs CompositionSELECTBIOenquiries@selectbiosciences.com
The complement system is comprised of over 20 soluble and membrane bound proteins with critical roles in recognizing, binding, and removal of foreign particles as well as initiating and regulating innate and acquired immune responses. Activation of the complement system occur during both normal (diurnal) and pathological conditions through any of the classical, alternative, or lectine pathways, that leads to insertion of the membrane attack complex (MAC, C5b-9) pore components in the plasma membrane. The result of MAC-induced exocytosis results in the formation and release in the extracellular space of: a) cytoplasmic components, mostly ions and small molecules, and b) plasma membrane derived vesicles into circulation. This mechanism requires Ca++, calpain activation and local disruption of the actin cytoskeleton. We hypothesized that the size of the C5b-9 complex, about 10 nm, is large enough to allow cellular miRNA species located near the plasma membrane to be released extracellularly.
Add to Calendar ▼2016-03-22 10:00:002016-03-22 11:00:00Europe/LondonThe Role of Terminal Complement Components in Plasma miRNAs CompositionSELECTBIOenquiries@selectbiosciences.com
