Carmen Gerlach's Biography

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CX3CR1 Distinguishes Three Distinct Migratory Memory CD8 T-cell Subsets

Wednesday, 2 November 2016 at 15:00

Add to Calendar ▼2016-11-02 15:00:002016-11-02 16:00:00Europe/LondonCX3CR1 Distinguishes Three Distinct Migratory Memory CD8 T-cell SubsetsCancer Immunotherapy and Biofluid Biopsies 2016 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com

CD8⁺ T cells are crucial for the protection against tumors and intra-cellular pathogens via their ability to generate long-term memory. Memory T cells are however not a homogeneous population. Traditionally, they have been sub-divided into central memory (T_CM), effector memory (T_EM) and tissue-resident memory (T_RM) cells based on different migration behaviors and cytotoxic potential.
We recently discovered the existence of a novel subset of memory CD8⁺ T cells that has unique migratory properties and a superior homeostatic self-renewal capacity. It is tempting to speculate that this subset may be an interesting population in the context of vaccination or adoptive T cell therapy.