Optimisation of P2Y12 Receptor Antagonists for the Treatment of Arterial Thrombosis: Receptor Kinetics and Pharmacodynamic RelevanceTuesday, 18 February 2014 at 11:30 Add to Calendar ▼2014-02-18 11:30:002014-02-18 12:30:00Europe/LondonOptimisation of P2Y12 Receptor Antagonists for the Treatment of Arterial Thrombosis: Receptor Kinetics and Pharmacodynamic RelevanceDiscovery Chemistry Congress in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com Antagonism of the P2Y12 receptor results in successful anti-platelet aggregation therapies. The lead optimisation of a series of P2Y12 antagonists with respect to anticoagulation effects, physicochemical and absorption profiles is presented. The observed in vivo effects and pharmacodynamic-pharmacokinetic profiles are discussed in light of the recorded P2Y12 receptor kinetic and the emerging structure-kinetic-relationships. |