Shlomit Kenigsberg,
Senior Researcher,
Create Fertility Centre
I am currently a senior researcher and lead for the Ovarian Biology Research group at CReATe Fertility Centre. My research is primarily focused on the isolation and characterizing of exosomes that are secreted from granulosa cells (GLCs) into follicular fluid (FF), and to study their unique RNAs (miRNome) and protein (Proteome) content. We plan to look for differences in exosomes content between different fertility-related patient groups. My long term goals are to 1) provide serum-based biomarkers to help asses a patient’s fertility potential and diagnosis, and 2) to discover potential FF biomarkers to assess egg quality and potential to create a healthy embryo.
The Journey to Human Follicular Maturation: The Story as told by Exosomes
Friday, 8 April 2016 at 15:30
Add to Calendar ▼2016-04-08 15:30:002016-04-08 16:30:00Europe/LondonThe Journey to Human Follicular Maturation: The Story as told by ExosomesExosomes and Liquid Biopsies Asia 2016 in Taipei, TaiwanTaipei, TaiwanSELECTBIOenquiries@selectbiosciences.com
Extracellular vesicles (EVs), including exosomes (60-180nm), are actively secreted by cells and tissues and have been described and characterized in all body fluids tested so far, including semen, CSF, synovial fluid, etc. They contain distinct subsets of DNA, RNAs, proteins and lipids, and are ideal non-invasive diagnostic biomarkers because they represent cell-derived signals. Follicular fluid (FF) provides part of the microenvironment that regulates oocyte development and thus, may play a critical role in oocyte fertilization and embryo development. Intercellular signaling between granulosa cells (GLC), cumulus cells (CM), and the oocyte is required for proper folliculogenesis, ovulation, and hormonal secretion. These signals can be mediated by extracellular vesicles (EVs), such as exosomes. We applied multiple approaches to isolate and characterize and visualized EVs in FF (FFEs), that will be discuss in my talk. I will also discuss their potential as biomarkers for ovarian reserve and egg quality.
Add to Calendar ▼2016-04-07 00:00:002016-04-08 00:00:00Europe/LondonExosomes and Liquid Biopsies Asia 2016Exosomes and Liquid Biopsies Asia 2016 in Taipei, TaiwanTaipei, TaiwanSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2016-04-08 15:30:002016-04-08 16:30:00Europe/LondonThe Journey to Human Follicular Maturation: The Story as told by ExosomesExosomes and Liquid Biopsies Asia 2016 in Taipei, TaiwanTaipei, TaiwanSELECTBIOenquiries@selectbiosciences.com
