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SELECTBIO Conferences Epigenetics, microRNAs and non Coding RNAs in Disease

Nagy Habib's Biography



Nagy Habib, Chief of Service/Professor, Imperial College London

Professor Nagy Habib is Lead Clinician for the HPB Unit at Imperial College Healthcare NHS Trust and Head of the Department of HPB Surgery at Imperial College London. In June 2007 he was also appointed Pro Rector for Commercial Affairs at the university. Professor Habib is a translational researcher who pioneered the first clinical trial in the use of adenovirus and plasmid for the treatment of liver cancer, as well as the use of plasmid gene therapy in hydrodynamic gene delivery. He was also the first to publish from the West a clinical trial on the use of adult bone marrow-derived stem cells for the treatment of patients with liver insufficiency. He has followed and published on the evolution of molecular biology of tumours from oncogene, tumour suppressor gene, epigenetic modification, gene therapy, stem cell therapy, saRNA and RNA aptamers. He was the inventor and was co-author on the first publication to describe the use for radiofrequency in devices used in liver surgery (Habib 4X), as well as interventional endoscopy (Habib EndoHPB) and interventional radiology (Habib VesOpen).

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A Novel RNA Oligonucleotide Improves Liver Function and Inhibits Liver Carcinogenesis in vivo

Wednesday, 16 October 2013 at 11:45

Add to Calendar ▼2013-10-16 11:45:002013-10-16 12:45:00Europe/LondonA Novel RNA Oligonucleotide Improves Liver Function and Inhibits Liver Carcinogenesis in vivoSELECTBIOenquiries@selectbiosciences.com

Hepatocellular carcinoma (HCC) occurs predominantly in patients with liver cirrhosis. Therapies to simultaneously reduced tumour burden and improve liver function are limited. We designed short-activating RNAs (saRNA) to enhance expression of CCAAT/enhancer-binding protein-a (C/EBPa), a transcriptional regulator and activator of albumin gene expression. Intravenous injection of C/EBPa-saRNA in a cirrhotic rat model with multifocal liver tumours increased circulating serum albumin by over 30% showing evidence of improved liver function whilst tumour burden decreased by 80%.


Add to Calendar ▼2013-10-16 00:00:002013-10-17 00:00:00Europe/LondonEpigenetics, microRNAs and non Coding RNAs in DiseaseSELECTBIOenquiries@selectbiosciences.com