Fred van Leeuwen's Biography

Fred van Leeuwen, Group Leader, Netherlands Cancer Institute

Fred van Leeuwen performed his PhD studies on the role of the unusual DNA base J in antigenic variation of African trypanosomes. He performed his post-doctoral training at the Fred Hutchinson Cancer Research Center in Seattle where he identified Dot1 as a methyltransferase of H3K79, a conserved histone modification system on the nucleosome core. In 2004, he started his independent research group as Antoni van Leeuwenhoek Fellow and recently became staff member at the Netherlands Cancer Institute, Amsterdam. His lab currently investigates the function and regulation of Dot1 in yeast and mammals and mechanisms of histone turnover and inheritance.