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SELECTBIO Conferences Epigenetics, microRNAs and non Coding RNAs in Disease

Raymond Schiffelers's Biography



Raymond Schiffelers, Professor of Nanomedicine, University Medical Center Utrecht

Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He received an ERC Consolidator Grant in 2010 to investigate extracellular vesicles as biological drug delivery systems. After he moved to University Medical Center Utrecht in 2011 he became professor of nanomedicine working on bio-inspired and synthetic drug delivery systems. He coordinates two H2020 projects on this topic, B-SMART and EXPERT, is editor for the International Journal of Pharmaceutics, Journal of Controlled Release and Journal of Extracellular Vesicles, and is founder of EXCYTEX-an extracellular vesicle-based company. Since 2021 he also works part-time for Nanocell Therapeutics as VP Preclinical R&D and is president of the ETPN.

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Therapeutic Delivery of mIRNAs to Inhibit Tumor Angiogenesis

Wednesday, 16 October 2013 at 14:15

Add to Calendar ▼2013-10-16 14:15:002013-10-16 15:15:00Europe/LondonTherapeutic Delivery of mIRNAs to Inhibit Tumor AngiogenesisSELECTBIOenquiries@selectbiosciences.com

From a lentiviral screen of >1000 miRNAs, we identified several miRNAs with pronounced activity in in vitro angiogenesis assays. When inhibitory miRNAs were delivered to tumor tissue via local injection and electroporation or intravenous injection via an integrin-targeted nanoparticle we observed pronounced inhibition of tumor growth and angiogenesis. Aanalysis of the transcriptome after miRNA treatment revealed that several molecular targets for angiogenesis inhibtion were simulatenously regulated by a single miRNA species.


Add to Calendar ▼2013-10-16 00:00:002013-10-17 00:00:00Europe/LondonEpigenetics, microRNAs and non Coding RNAs in DiseaseSELECTBIOenquiries@selectbiosciences.com