Liang Wang,
Senior Member of Tumor Biology,
Moffitt Cancer Center
Dr. Wang is a senior member at the H. Lee Moffitt Cancer Center and a professor of oncology at the University of South Florida. He has more than 150 peer-reviewed publications. His research interest has been to apply genetics and genomics approach to identifying new biomarkers for cancer risk assessment, detection, and progression. Specifically, he is interested in studying genetic susceptibility of human cancers and biological mechanisms under the susceptibility. He is also interested in applying liquid biopsy technology for cancer early detection and outcome prediction. Dr. Wang’s studies are funded by multiple grants from National Institute of Healthy and other government agencies.
Effect of Plasma Exosome Isolation Methods on Multi-Omic Profiles in Cancer Patients and Healthy Controls
Wednesday, 26 July 2023 at 11:45
Add to Calendar ▼2023-07-26 11:45:002023-07-26 12:45:00Europe/LondonEffect of Plasma Exosome Isolation Methods on Multi-Omic Profiles in Cancer Patients and Healthy ControlsExtracellular Vesicles 2023: Technologies, Biomarker Cargo and Diagnostics in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com
Circulating exosomes in the blood are promising tools for biomarker discovery in cancer. Due to their heterogeneity, different isolation methods may enrich distinct exosome cargos generating different omic profiles. In this presentation, I will share our recent study on the effects of plasma exosome isolation methods on multi-omic profiles in cancer patients and healthy controls. This study evaluated three exosome isolation methods including size exclusion chromatography, lectin binding, and TIM4 binding. For each exosome isolation method, molecular profiling analysis was performed included lipidome, metabolome, proteome and transcriptome. Our study shows clear difference in molecular profiles of the exosomes isolated using different methods. Our findings suggest that specific isolation methods select subpopulations which may significantly impact cancer biomarker discovery.
Add to Calendar ▼2023-07-26 00:00:002023-07-27 00:00:00Europe/LondonExtracellular Vesicles 2023: Technologies, Biomarker Cargo and DiagnosticsExtracellular Vesicles 2023: Technologies, Biomarker Cargo and Diagnostics in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2023-07-26 11:45:002023-07-26 12:45:00Europe/LondonEffect of Plasma Exosome Isolation Methods on Multi-Omic Profiles in Cancer Patients and Healthy ControlsExtracellular Vesicles 2023: Technologies, Biomarker Cargo and Diagnostics in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com
