Larry Chamley's Biography

Larry Chamley, Professor and Head of Department of Obstetrics and Gynaecology, University of Auckland

Professor Larry Chamley is Head of the Department of Obstetrics and Gynaecology, at the University of Auckland, New Zealand where he heads a research group studying the biology and immunology of reproduction with a special focus on how placental EVs regulate maternal physiology. He is also the Director of the Hub for Extracellular Vesicles (HEVI) at The University of Auckland and is the Vice President of the American Society for Reproductive immunology. He has more than 200 publications and is the Editor of Trophoblast Research and an Associate Editor of Reproduction.

Placental Extracellular Vesicles; Regulators of Maternal Physiology

Wednesday, 29 November 2023 at 11:45

Add to Calendar ▼2023-11-29 11:45:002023-11-29 12:45:00Europe/LondonPlacental Extracellular Vesicles; Regulators of Maternal PhysiologyExtracellular Vesicles and Cell-Free RNAs 2023 in Laguna Hills, CaliforniaLaguna Hills, CaliforniaSELECTBIOenquiries@selectbiosciences.com

The human placenta produces vast quantities of extracellular vesicles into the maternal blood continuously during pregnancy. Biodistribution studies indicate that the majority of these EVs are taken up from the maternal blood rapidly in the lungs, liver kidneys and spleen. Functional studies demonstrate that normotensive placental EVs can protect against the development of hypertension long-term while EVs from pregnancies complicated by preeclampsia a hypertensive disease of pregnancy activate the maternal endothelium and induce a pro-constrictive phenotype in resistance arteries. These functional studies suggest that the protein and/or regulatory RNA cargos of placental EVs have a long-lasting regulatory effect on the maternal cardiovascular system.

Add to Calendar ▼2023-11-28 00:00:002023-11-30 00:00:00Europe/LondonExtracellular Vesicles and Cell-Free RNAs 2023Extracellular Vesicles and Cell-Free RNAs 2023 in Laguna Hills, CaliforniaLaguna Hills, CaliforniaSELECTBIOenquiries@selectbiosciences.com

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