Samir EL-Andaloussi's Biography

Samir EL-Andaloussi, Associate Professor, Karolinska Institutet

Samir EL Andaloussi received his PhD in 2008 in Neurochemistry with Molecular Neurobiology at Stockholm University. After a postdoctoral stint at Karolinska Institutet, he moved to University of Oxford to work with extracellular vesicles (EVs). Since 2013 Associate Professor Samir is a Principal Investigator for a growing lab at Karolinska Institutet, now with nearly 20 employees. His lab primarily focuses on developing non-viral drug delivery systems for nucleic acids and proteins with particular focus on production of engineered exosomes for delivery of biotherapeutics. In addition, Samir in one of the Founders of Evox Therapeutics, a company developing engineered EVs for treatment of genetic diseases.

Gene Editing and Targeted Delivery Using Engineered Extracellular Vesicles

Monday, 13 November 2023 at 11:15

Add to Calendar ▼2023-11-13 11:15:002023-11-13 12:15:00Europe/LondonGene Editing and Targeted Delivery Using Engineered Extracellular VesiclesExtracellular Vesicles and Nanoparticle-based Therapeutics Europe 2023 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication due to their ability to transfer bioactive lipids, proteins and different species of RNA into cells. As such, EVs can be harnessed for the delivery of macromolecular drugs. Adapting EVs for drug delivery requires cellular engineering that allows for selective loading of biotherapeutics inside or on the surface of EVs. This presentation will cover our recent developments in EV engineering, with focus on active loading and functional delivery of gene editing modalities. In addition to addressing PK, PD and functional delivery of EVs in normal and diseased mice, strategies to enhance tissue targeting and extending plasma half-life of circulating EVs will be discussed.

Add to Calendar ▼2023-11-13 00:00:002023-11-14 00:00:00Europe/LondonExtracellular Vesicles and Nanoparticle-based Therapeutics Europe 2023Extracellular Vesicles and Nanoparticle-based Therapeutics Europe 2023 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

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