Heather Branscome,
Senior Scientist, ATCC and Research Assistant,
George Mason University
Heather Branscome is Senior Scientist at the American Type Culture Collection (ATCC). She is also affiliated with George Mason University as a Research Assistant. She has over 15 years of cross-functional experience working in cell and molecular biology to support various activities including product development, technology transfer, biomanufacturing, and quality control. In her current role she manages the Cell Biology Bioproduction and Preservation departments. She earned her MS in Cell and Molecular Biology from George Mason University and earned her PhD in Biosciences from George Mason University. Her primary research interests surround large-scale manufacturing of EVs and the functional analysis of stem cell EVs in the context of cellular repair.
Large Scale Manufacturing and Functional Assessment of Extracellular Vesicles
Thursday, 27 July 2023 at 13:30
Add to Calendar ▼2023-07-27 13:30:002023-07-27 14:30:00Europe/LondonLarge Scale Manufacturing and Functional Assessment of Extracellular VesiclesExtracellular Vesicles 2023: Drug Delivery, Biologics and Therapeutics in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com
The interest in extracellular vesicles (EVs) underlies a significant need for both the isolation of high quality EVs from large-scale batches and the development of industry standards for the characterization and quality control testing of EVs. While traditional methods, which include the use of ultracentrifugation and density gradients, are suitable for small-scale studies, the development of scalable and robust processes for the isolation of EVs is essential to meet the growing needs of the scientific community. Here, we report the large-scale isolation and characterization of functional EVs from both cancer cell lines and stem cells. Collectively, we demonstrate our ability to reproducibly manufacture production-scale batches of high quality EVs from multiple different cell types. Our EVs are of high yield, meet well-established quality control specifications, and are robust in maintaining size distribution, surface marker expression, and functionality in vitro. Therefore, they can serve as ideal reference materials that can support a wide range of different EV-based research applications.
Add to Calendar ▼2023-07-26 00:00:002023-07-27 00:00:00Europe/LondonExtracellular Vesicles 2023: Drug Delivery, Biologics and TherapeuticsExtracellular Vesicles 2023: Drug Delivery, Biologics and Therapeutics in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2023-07-27 13:30:002023-07-27 14:30:00Europe/LondonLarge Scale Manufacturing and Functional Assessment of Extracellular VesiclesExtracellular Vesicles 2023: Drug Delivery, Biologics and Therapeutics in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com
