miRNA Modifications Play a Pivotal Role in B-cell MalignanciesWednesday, 27 April 2011 at 16:00 Add to Calendar ▼2011-04-27 16:00:002011-04-27 17:00:00Europe/LondonmiRNA Modifications Play a Pivotal Role in B-cell MalignanciesEpigenetics World Congress in BostonBostonSELECTBIOenquiries@selectbiosciences.com Epigenetic modifications play a pivotal role in the pathogenesis of hematologic malignancies, including Waldesntrom’s Macroglobulinemia (WM) and Multiple Myeloma (MM). MicroRNA (miRNA) expression profiling of primary WM and MM tumor cells has demonstrated a clear miRNA signature in these B-cell malignancies. Moreover, functional studies have revealed the crucial role of miRNA-155 and miRNA-15a/16-1 in regulating the biology of WM and MM, respectively, thus providing the rational for using miRNA-based therapeutic strategies in these diseases. |