Gordon Saxty's Biography

Gordon Saxty, Associate Director/Chair, Astex Therapeutics

Gordon Saxty did his Masters in Medicinal Chemistry at the University of Manchester (UMIST) where, as part of the programme, he also worked at Sanofi-Aventis (formally RPR). He then went on to do a PhD in Synthetic Organic Chemistry at Imperial College, London under the supervision of Prof Donald Craig. Currently he holds the position of Associate Director at Astex Pharmaceuticals Inc in Cambridge, UK where he has worked for the last 10 years directly on Fragment Based Drug Discovery programmes, some of which are now in clinical trails. Other activities include being a member of the RSC-BMCS committee.

Fragment Based Drug Discovery of Selective Inhibitors of Fibroblast Growth Factor Receptor

Tuesday, 13 March 2012 at 14:45

Add to Calendar ▼2012-03-13 14:45:002012-03-13 15:45:00Europe/LondonFragment Based Drug Discovery of Selective Inhibitors of Fibroblast Growth Factor Receptor SELECTBIOenquiries@selectbiosciences.com

A fragment screening campaign was conducted against the tyrosine kinase domain of FGFR1 to detect low molecular weight compounds. The talk will demonstrate a F2L campaign from a 120 uM hit to 0.003 uM (in FGFR3) with activity in an FGFR driven xenograft model when dosed by the oral route.

Add to Calendar ▼2012-03-13 00:00:002012-03-14 00:00:00Europe/LondonFragment Based Lead DiscoverySELECTBIOenquiries@selectbiosciences.com

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