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SELECTBIO Conferences Fragment Based Lead Discovery

Maria Costi's Biography



Maria Costi, Associate Professor, University of Modena and Reggio Emilia

Education. 1984: degree in Chemistry and Pharmaceutical Science, University of Modena, Modena, Italy, 1985: degree in Pharmacy, University of Modena, 1989: PhD in Medicinal Chemistry, University of Milan-Modena-Trieste, Italy.
Brief Chronology of Employment: -1990: Research position in the Faculty of Pharmacy, Modena, Department of Pharmaceutical Science. -1991: Visiting fellow, Department of Biochemistry and Biophysics, Directed by Prof. D.V.Santi. University of California San Francisco, US. Back in the same lab as Visiting scientist in 1994, 1996, 1998, 1999. -1992-1993: Post doctoral fellow, Department of Pharmaceutical Science, Prof. P.G. Baraldi. University of Ferrara, Ferrara, Italy. -1993-1999 Permanent Researcher position, Department of Pharmaceutical Science, University of Modena, Modena, Italy. -2000- 2009. Associate Professor in Medicinal Chemistry, Faculty of Bioscience and Biotechnology, University of Modena, Modena, Italy. -2010- Full Professor in Medicinal Chemistry, Faculty of Bioscience and Biotechnology, University of Modena and Reggio Emilia (UNIMORE), Modena, Italy.Teaching activity. Medicinal chemistry and Advanced methodologies in Drug Discovery, Laboratory of biotechnological drugs, protein purification in the Faculty of Bioscience and Biotechnology. In the past 15 years she has been teaching 10 different subjects within Analytical Chemistry, Medicinal chemistry, Drug Design in the Faculty of Pharmacy. School of Doctorate in Health Science teaching topics related to System biology approaches to drug discovery.

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Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry

Wednesday, 20 March 2013 at 11:15

Add to Calendar ▼2013-03-20 11:15:002013-03-20 12:15:00Europe/LondonFragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass SpectrometrySELECTBIOenquiries@selectbiosciences.com

A fragment-based Mass Spectrometry approach has been applied to identify small molecules that can bind to the monomeric interface of Thymidylate synthase. The identified compounds behave as protein-protein interaction inhibitors. 


Add to Calendar ▼2013-03-19 00:00:002013-03-20 00:00:00Europe/LondonFragment Based Lead Discovery SELECTBIOenquiries@selectbiosciences.com