Wu Jie,
Associate Professor, Chemistry Department,
National University of Singapore
Jie obtained his PhD in 2012 with Prof. James S. Panek at Boston University working on natural product total synthesis. In his postdoc research at MIT with Prof. Timothy Jamison and Prof. Alan Hatton, Jie has been exposed to the hard core of continuous flow chemistry. Since joining NUS in July 2015, his research group focuses on new synthetic methodology development using photocatalysis assisted by advanced flow technologies. His group is also interested in the development of advanced flow technologies for on-demand and automated synthesis of functionalized organic molecules. In July 2021, Jie was promoted to tenured associate professor. His research group has published more than 100 papers in these research areas, with more than 10 filed patents. Jie is a recipient of Dean’s Chair Professor (2023), Tokyo Chemical Industry-SNIC Industry Award in Synthetic Chemistry (2021), NUS Young Research Award (2021), Yong Scientist Award (2020), Asian Core Program Lectureship Award (2017-2022), Thieme Chemistry Journal Award (2019), and NUS Chemistry Department Young Chemist Award (2018).
Automated Scalable Synthesis Enabled by High-Speed Circulation Flow
Sunday, 7 June 2026 at 14:30
Add to Calendar ▼2026-06-07 14:30:002026-06-07 15:30:00Europe/LondonAutomated Scalable Synthesis Enabled by High-Speed Circulation FlowFlow Chemistry Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com
Automated multistep synthesis of small organic molecules remains a formidable challenge, as conventional batch platforms are often limited by scalability, while continuous-flow systems face difficulties in handling solids, slow reactions, and compatibility across multiple steps. In this presentation, I will introduce a modular automated multistep synthesis platform built around high-speed circulating flow (HSCF) reactors that integrate the strengths of both batch and flow approaches. This architecture enables the direct adoption of literature-reported protocols across homogeneous, heterogeneous, and photochemical transformations for scalable multistep synthesis. Two platform configurations were demonstrated: an “all-in-one” setup enabling fully automated synthesis of brexpiprazole (>25 g) within a compact footprint, and an “integrated flow” platform facilitating the semi-continuous production of esonarimod and two benzoxazinone derivatives at rates exceeding 10 g/day. We establish a universal, scalable, and reconfigurable architecture that significantly advances automated multistep synthesis, offering a practical solution for the on-demand production of functional small molecules.
Add to Calendar ▼2026-06-06 00:00:002026-06-07 00:00:00Europe/LondonFlow Chemistry Asia 2026Flow Chemistry Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2026-06-07 14:30:002026-06-07 15:30:00Europe/LondonAutomated Scalable Synthesis Enabled by High-Speed Circulation FlowFlow Chemistry Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com
