Fanfu Guan received his BSc degree from Hongkong Polytechnic University. After obtaining his master degree from Polytechnic Institute of Toulouse in 2017, he got his PhD degree from University of Leeds in 2021, under the supervision of Prof. John Blacker and Prof. Xumu Zhang. He joined Hengrui Pharmaceuticals as the head of flow chemistry team in October 2021. He led the development and construction of multiple commercial-scale GMP flow chemistry processes with annual hundred tons capacities, including flash chemistry, fixed-bed hydrogenation, oxidation and nanoparticle production. His research focuses on flow chemistry, continuous manufacturing, transition metal catalysis, drug formulation and mechanistic investigation. He has published 11 peer-reviewed papers in Angewandte Chemie, Reaction chemistry and Engineering, Chemical Science and so on.
Process Development of a Diastereopure Drug Intermediate via Flash Chemistry, Continuous Packed-bed Hydrogenation and Enzymatic Kinetic Resolution
Saturday, 6 June 2026 at 14:40
Add to Calendar ▼2026-06-06 14:40:002026-06-06 15:40:00Europe/LondonProcess Development of a Diastereopure Drug Intermediate via Flash Chemistry, Continuous Packed-bed Hydrogenation and Enzymatic Kinetic ResolutionFlow Chemistry Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com
New technologies, such as continuous flow chemistry and enzymatic catalysis, are reshaping drug development and production, assisting in synthesis of drug with precision. HRS-1358 is a novel PROTAC molecule designed to target and degrade the estrogen receptor (ER). It potently and selectively degrades ER, inhibits ER transcriptional activity and downstream signaling, thereby suppressing tumor cell proliferation and exerting anti-tumor effects. The synthesis of key drug intermediate 1 possessing two sterically hindered adjacent stereocenters lacking chelating heteroatoms, presents significant challenges. To meet the clinical trial demands, the new synthetic route in Figure 1 was developed by adopting continuous flash chemistry, continuous packed bed hydrogenation and enzymatic kinetic resolution, raising the yield by two-fold to 32.5% and reducing the step to three steps.
Add to Calendar ▼2026-06-06 00:00:002026-06-07 00:00:00Europe/LondonFlow Chemistry Asia 2026Flow Chemistry Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2026-06-06 14:40:002026-06-06 15:40:00Europe/LondonProcess Development of a Diastereopure Drug Intermediate via Flash Chemistry, Continuous Packed-bed Hydrogenation and Enzymatic Kinetic ResolutionFlow Chemistry Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com
