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Continuous Flow Metallaphotoredox Stereodivergent Semi-hydrogenation and Semi-deuterogenation of Alkynes

Sunday, 7 June 2026 at 12:00

Add to Calendar ▼2026-06-07 12:00:002026-06-07 13:00:00Europe/LondonContinuous Flow Metallaphotoredox Stereodivergent Semi-hydrogenation and Semi-deuterogenation of AlkynesFlow Chemistry Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com

Alkenes are ubiquitous structural motifs in pharmaceuticals, agrochemicals, and materials science, while their stereoselective synthesis has been a pivotal endeavour in organic chemistry.  Stereoselective semi-hydrogenations provide straightforward access to both E- and Z-alkenes from readily available alkyne precursors, but traditional methods often suffer from poor scalability, over-reduction, limited substrate scope, and reliance on hydrogen gas.  Herein, we discuss two metallaphotoredox systems that enable stereodivergent semi-hydrogenation and semi-deuterogenation of alkynes.  We reveal new factors that control the stereoselectivity of both reactions, such as by varying the acid co-catalysts or the residence time in flow.  Both E- and Z-alkenes are obtained with excellent stereoselectivity and broad functional group tolerance.  Water serves as the primary hydrogen source, while cost-efficient and readily available reagents and ligands are used.  Our reactions can be readily scaled-up in flow without compromising yield and stereoselectivity.