Rapid and Column-Chromatography-Free Flow-Peptide Chain ElongationThursday, 5 October 2023 at 11:15 Add to Calendar ▼2023-10-05 11:15:002023-10-05 12:15:00Europe/LondonRapid and Column-Chromatography-Free Flow-Peptide Chain ElongationFlow Chemistry Asia 2023 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com Peptides have become increasingly important as drugs. In this study, we developed rapid, mild and column-free peptide chain elongation via one-flow, three-component coupling approach using amino acid N-carboxy anhydride (NCA) which has both nucleophilicity and electrophilicity. The key to success was the rapid generation of acid chloride from amino acid and its rapid coupling with NCA via rapid dual activation. |