Remko de Pril's Biography

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High Content Screen for Inhibitors of Cell Migration in Cancer Metastasis Using Adenoviral Knock-Down

Thursday, 30 June 2011 at 16:00

Add to Calendar ▼2011-06-30 16:00:002011-06-30 17:00:00Europe/LondonHigh Content Screen for Inhibitors of Cell Migration in Cancer Metastasis Using Adenoviral Knock-DownSELECTBIOenquiries@selectbiosciences.com

Enhanced cell migration is a hallmark of metastatic cancer cells. The propensity of cancer cells to close an open wound in a cell monolayer is thought to predict this ability. Using our adenoviral shRNA knock-down library we have established a high-throughput wound healing assay to identify novel genes involved in cell migration. We demonstrated that two knock-down constructs targeting a known player in motility, CXCR4, inhibit wound healing, thereby validating our approach.