Dr. Djaballah has several years of industrial experience in early drug discovery gained over the years in pharma and biotech companies. He has extensive experiences in the areas of fluorescence technology, assay development, automation/robotics, HTS, compound & screening data management, software development & novel technologies. Dr Djaballah has been involved in developing and screening several targets in various therapeutic areas, including antibacterials, antivirals, antifungals, diabetes, CNS, cardiovascular, oncology & inflammation. He is currently the director of the high throughput drug screening core facility at Memorial Sloan Kettering Cancer Centre in New York. He obtained his BSc (Hons.) in biochemistry and biotechnology from the University of Birmingham, and his PhD in biochemistry from the University of Leicester, both in England.
A Biosensor Based High Content Screen for Modulators of the EGFR Receptor: Merits of Live Cell Based Assays?
Thursday, 30 June 2011 at 17:30
Add to Calendar ▼2011-06-30 17:30:002011-06-30 18:30:00Europe/LondonA Biosensor Based High Content Screen for Modulators of the EGFR Receptor: Merits of Live Cell Based Assays?SELECTBIOenquiries@selectbiosciences.com
Traditional drug discovery approaches to identify EGFR modulators has long been associated with screening recombinant kinase domains in vitro against large or focused chemical libraries; often with limited success due primarily to lack of activity in cell based follow up studies. Using a recently developed domain based biosensor technology; a high content assay was developed and validated in an established cell line allowing real time monitoring of EGFR activation and internalization. I will be presenting our results and discuss the application of this novel biosensor screening technology to other signaling receptors; for which no drugs are currently available.
Add to Calendar ▼2011-06-30 00:00:002011-07-01 00:00:00Europe/LondonScreening Europe - HCS and AssaysSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2011-06-30 17:30:002011-06-30 18:30:00Europe/LondonA Biosensor Based High Content Screen for Modulators of the EGFR Receptor: Merits of Live Cell Based Assays?SELECTBIOenquiries@selectbiosciences.com
