Louise Laurent,
Associate Professor,
University of California-San Diego
Louise Laurent is Associate Professor in Reproductive Medicine at the University of California, San Diego. She received her residency training in Obstetrics and Gynecology and her clinical fellowship training in Maternal Fetal Medicine at UC San Diego. Her graduate research at UCSF included a large scale mutagenesis and molecular tracking strategy to define the regions of the HIV genome necessary for viral replication in the laboratory of Patrick O. Brown, M.D. / Ph.D. As a clinical fellow, she worked with Jeanne Loring, Ph.D. at The Scripps Research Institute to delineate the expression of miRNAs in human embryonic stem cells. Her current research focuses on applying genomic and epigenomic methods to understanding the molecular regulation of pluripotency and differentiation, optimizing the preclinical and clinical utility of human pluripotent stem cells, and identifying the molecular basis of placental dysfunction in human pregnancy.
Extracellular RNAs in the Maternal Circulation: A Window into Placental Function
Monday, 16 November 2015 at 15:00
Add to Calendar ▼2015-11-16 00:00:002015-11-16 01:00:00Europe/LondonExtracellular RNAs in the Maternal Circulation: A Window into Placental FunctionSELECTBIOenquiries@selectbiosciences.com
Critical to the success of the pregnancy is the rapid development of a
new organ, the placenta, which is of fetal origin, but which must gain
access to the maternal bloodstream. This direct contact between
placental trophoblast cells and the maternal circulation facilitates the
functions of these cells, both as mediators of the exchange of
materials between the fetus and the mother, and as sources of signaling
molecules that induce changes in maternal physiology necessary for the
establishment and maintenance of the pregnancy, such as progesterone,
human chorionic gonadotropin and human placental lactogen. It is
reasonable, then, to hypothesize that both the physiological changes
occurring over the course of normal pregnancy and the pathological
changes taking place with complications of pregnancy, are reflected in
the ExRNA profiles of maternal biofluids, and may even be partially
mediated by ExRNA signals. Here, we will discuss evidence that ExRNAs in
the maternal circulation indeed reflect changes in placental function
during pregnancy.
Add to Calendar ▼2015-11-16 00:00:002015-11-17 00:00:00Europe/LondonHigh-Value DiagnosticsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2015-11-16 00:00:002015-11-16 01:00:00Europe/LondonExtracellular RNAs in the Maternal Circulation: A Window into Placental FunctionSELECTBIOenquiries@selectbiosciences.com
