Jianping Fu,
Professor, Mechanical Engineering, Biomedical Engineering, Cell & Developmental Biology,
University of Michigan-Ann Arbor
Dr. Jianping Fu is a Professor of Mechanical Engineering, Biomedical Engineering, and Cell & Developmental Biology at the University of Michigan. Dr. Fu’s research focuses on stem cell bioengineering, developmental bioengineering, mechanobiology, and microfluidics. Dr. Fu and his co-workers' research has contributed significantly to the emerging field of "Artificial Embryos", which was selected by the MIT Technology Review as “10 Breakthrough Technologies of 2018”. Dr. Fu is the recipient of the NSF CAREER Award, the BMES-CMBE Rising Star Award, the ACS Analytical Chemistry Young Innovator Award, the Alexander von Humboldt Foundation Friedrich Wilhelm Bessel Research Award, and numerous awards from the University of Michigan. Dr. Fu is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE), the Royal Society of Chemistry (RSC), the American Society of Mechanical Engineers (ASME), the International Academy of Medical and Biological Engineers (IAMBE), and the Biomedical Engineering Society (BMES). Dr. Fu was a member of the International Society for Stem Cell Research (ISSCR) Guidelines Working Group from 2019 to 2021 and is currently a member of the ISSCR Publications Committee. He is a council member of the Biomedical Engineering Society Cellular and Molecular Bioengineering Special Interest Group (BMES CMBE-SIG). Dr. Fu currently serves as the Associate Editor of npj Regenerative Medicine and is an Editorial or Advisory Board Member of Cell Stem Cell, Biophysical Journal, Cell Regeneration, Mechanobiology in Medicine, and Frontiers in Cell and Developmental Biology. Additionally, Dr. Fu is a Founding Member of the Catalysts Program of EMBO Journal.
Bioengineered Human Embryo and Organ Models
Tuesday, 7 May 2024 at 11:00
Add to Calendar ▼2024-05-07 11:00:002024-05-07 12:00:00Europe/LondonBioengineered Human Embryo and Organ ModelsInnovations in Microfluidics 2024: Rapid Prototyping, 3D-Printing in Ann Arbor, MichiganAnn Arbor, MichiganSELECTBIOenquiries@selectbiosciences.com
Early human development remains mysterious and difficult to study. Recent advances in developmental biology, stem cell biology, and bioengineering have contributed to a significant interest in constructing controllable, stem cell-based models of human embryo and organs (embryoids / organoids). The controllability and reproducibility of these human development models, coupled with the ease of genetically modifying stem cell lines, the ability to manipulate culture conditions and the simplicity of live imaging, make them robust and attractive systems to disentangle cellular behaviors and signaling interactions that drive human development. In this talk, I will describe our effort in using human pluripotent stem cells (hPSCs) and bioengineering tools to develop controllable models of the peri-implantation embryonic development and early neural development. The peri-implantation human embryoids recapitulate early post-implantation developmental landmarks successively, including amniotic cavity formation, amniotic ectoderm-epiblast patterning, primordial germ cell specification, development of the primitive streak, and yolk sac formation. I will further discuss an hPSC-based, microfluidic neural tube-like structure (or µNTLS), whose development recapitulates some critical aspects of neural patterning in both brain and spinal cord regions and along both rostral-caudal and dorsal-ventral axes. The µNTLS is further utilized for studying development of different neuronal lineages, revealing pre-patterning of axial identities of neural crest progenitors and functional roles of neuromesodermal progenitors and caudal gene CDX2 in spinal cord and trunk neural crest development. We have further developed dorsal-ventral patterned, microfluidic forebrain-like structures (µFBLS) with spatially segregated dorsal and ventral regions and layered apicobasal cellular organizations that mimic human embryonic brain development in pallium and subpallium areas, respectively. Together, both µNTLS and µFBLS offer 3D lumenal tissue architectures with an in vivo-like spatiotemporal cell differentiation and organization, useful for studying human neurodevelopment and disease.
Add to Calendar ▼2024-05-06 00:00:002024-05-07 00:00:00Europe/LondonInnovations in Microfluidics 2024: Rapid Prototyping, 3D-PrintingInnovations in Microfluidics 2024: Rapid Prototyping, 3D-Printing in Ann Arbor, MichiganAnn Arbor, MichiganSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2024-05-07 11:00:002024-05-07 12:00:00Europe/LondonBioengineered Human Embryo and Organ ModelsInnovations in Microfluidics 2024: Rapid Prototyping, 3D-Printing in Ann Arbor, MichiganAnn Arbor, MichiganSELECTBIOenquiries@selectbiosciences.com
