George Alexandrakis's Biography

George Alexandrakis, Professor, Bioengineering Department, University of Texas at Arlington

Dr. Alexandrakis performed his undergraduate work in Physics at Oxford University. He then obtained Master’s and PhD degrees in Medical Physics from McMaster University in Canada. He was postdoctoral fellow at Massachusetts General Hospital, Harvard Medical School and UCLA before joining the faculty at the University of Texas at Arlington. His current interests are focused on developing ultra-sensitive nanosensors for screening protein-ligand interactions in cancer immunotherapy and on novel nanopore-based methods to test the quality gene therapy vehicles and other therapeutic nanoparticles.

Plasmonic Nanopore Sensing with Multi-Frequency Burst and Continuous AC Modulation

Thursday, 26 September 2024 at 16:00

Add to Calendar ▼2024-09-26 16:00:002024-09-26 17:00:00Europe/LondonPlasmonic Nanopore Sensing with Multi-Frequency Burst and Continuous AC ModulationEmerging Technologies for Diagnostics and Liquid Biopsies - New Orleans 2024 in New OrleansNew OrleansSELECTBIOenquiries@selectbiosciences.com

The use of plasmonic nanopores for single molecule detection has attracted considerable attention due to their high sensitivity and selectivity. I will present my group’s work on a phase analysis approach for characterizing the trapping of single molecules in a plasmonic nanopore using trains of multi-frequency AC bursts or continuous AC modulation. By analyzing the phase response of the plasmonic nanopore at select frequencies, we can differentiate between a test ligand, the antibody targeting this ligand, and the complexes that these ligands form, as well as observe their dynamics while inside the optical trap of the plasmonic nanopore. This work shows the feasibility of these two new approaches for rapid and accurate identification of single molecules in complex mixtures.

Add to Calendar ▼2024-09-26 00:00:002024-09-27 00:00:00Europe/LondonEmerging Technologies for Diagnostics and Liquid Biopsies - New Orleans 2024Emerging Technologies for Diagnostics and Liquid Biopsies - New Orleans 2024 in New OrleansNew OrleansSELECTBIOenquiries@selectbiosciences.com

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