Mike Makrigiorgos's Biography

Mike Makrigiorgos, Professor, Dana-Farber Cancer Institute/Harvard Medical School

Dr. Makrigiorgos is Professor and Director of the Medical Physics and Biophysics Division of the combined Radiation Oncology Department at Dana Farber Cancer Institute, Brigham and Women’s and Children’s Hospitals, at Harvard Medical School, Boston, USA. He is also Director of the DNA technology laboratory and the radiation pre-clinical facility. He is a Member of the Editorial Board of Clinical Chemistry and has published over 100 articles, reviews and book chapters. His research interests include the development of novel DNA technologies for molecular diagnostics with application in Oncology. He is the inventor of several novel PCR-based techniques for molecular diagnostics, including Balanced-PCR, Anti-primer-quenching-real-time PCR, Hairpin-PCR and COLD-PCR.

Novel Approaches for Increasing Sensitivity and Specificity of Molecular Diagnostics Assays Following Mutation Enrichment

Monday, 21 March 2016 at 15:00

Add to Calendar ▼2016-03-21 15:00:002016-03-21 16:00:00Europe/LondonNovel Approaches for Increasing Sensitivity and Specificity of Molecular Diagnostics Assays Following Mutation EnrichmentSELECTBIOenquiries@selectbiosciences.com

Detecting rare mutations in clinical samples and liquid biopsies requires methods having highly increased sensitivity while retaining excellent specificity. We developed novel methods that provide mutation enrichment either prior to PCR or during PCR and enable established methodologies for detecting mutations at 0.1-0.01% levels or below. We present the advantages of combining a novel approach, NaME (Nuclease-assisted Mutation Enrichment) with COLD-PCR, digital PCR, high resolution melting or sequencing.

Add to Calendar ▼2016-03-21 00:00:002016-03-22 00:00:00Europe/LondonRNA-Seq, Digital PCR, and Liquid Biopsies: Capturing Value from Circulating BiomarkersSELECTBIOenquiries@selectbiosciences.com

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