Susan M. Lunte is the Ralph N. Adams Distinguished Professor of Chemistry and Pharmaceutical Chemistry and Director of the Adams Institute for Bioanalytical Chemistry at the University of Kansas, Lawrence, KS. She is a fellow of the American Association of Pharmaceutical Sciences and the Royal Society of Chemistry. In 2004, Dr. Lunte was the recipient of the AAPS Research Achievement Award in Analysis and Pharmaceutical Quality. She was awarded a Science Foundation of Ireland Walton Fellowship through Dublin City University in 2006. Susan was the chair of the Analytical Division of the American Chemical Society in 2011. She is currently the Associate Editor for the Americas for Analytical Methods. Her research interests include the development of microfluidic based methodologies for separation and detec¬tion of peptides, amino acids, neuro¬trans¬mitters and pharmaceuticals in biological fluids.
Separation-based Sensors for Monitoring Drug Metabolism and Neurotransmitters in Freely Roaming Animals
Thursday, 18 September 2014 at 17:45
Add to Calendar ▼2014-09-18 17:45:002014-09-18 18:45:00Europe/LondonSeparation-based Sensors for Monitoring Drug Metabolism and Neurotransmitters in Freely Roaming AnimalsLab-on-a-Chip, Microfluidics and Microarray World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Most behavioral studies using microdialysis sampling require tethering of the animal to the microdialysis system so that the animal is freely moving but not freely roaming. In this paper, we describe an on-animal separation-based sensor that combines microdialysis sampling with microchip electrophoresis. The goal is to develop a miniaturized device that can be placed on-animal and is capable of continuous monitoring of drug and neurotransmitter concentrations in the brains of freely roaming sheep. Such a device, combined with video recording, will make it possible to directly correlate neurochemistry with animal behaviour. Microchip electrophoresis is employed for the analysis since it makes possible the separation and detection of several analytes simultaneously with good temporal resolution. Analytes are detected using electrochemical detection, a mode particularly well-suited to such portable analysis systems since the electrode and the potentiostat are easily miniaturized. The current on-animal system is about the size of a lunch box and is run by a laptop battery. The instrument is remotely controlled using telemetry. This system was first demonstrated by monitoring the generation of nitric oxide from subcutaneous infusions of nitroglycerin in freely roaming sheep. Recent progress in the development of an on-animal sensor for the continuous monitoring of biogenic amines in brain microdialysis samples will be presented.
Add to Calendar ▼2014-09-18 00:00:002014-09-19 00:00:00Europe/LondonLab-on-a-Chip, Microfluidics and Microarray World CongressLab-on-a-Chip, Microfluidics and Microarray World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2014-09-18 17:45:002014-09-18 18:45:00Europe/LondonSeparation-based Sensors for Monitoring Drug Metabolism and Neurotransmitters in Freely Roaming AnimalsLab-on-a-Chip, Microfluidics and Microarray World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
