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SELECTBIO Conferences Lab-on-a-Chip, Microfluidics & Microarray World Congress

Martyn Boutelle's Biography



Martyn Boutelle, Professor of Biomedical Sensors Engineering, Vice Chair Department of Bioengineering, Imperial College London

After an initial undergraduate training in Chemistry and a PhD in Electrochemistry at Imperial College London. I worked as a research fellow in the University Laboratory of Physiology, University of Oxford using implantable electrochemical sensors and microdialysis probes to study brain neurochemistry. This work was extended to clinical monitoring of the injured brain when I moved to the Department of Chemistry, King’s College London. I moved to the Department of Bioengineering at Imperial College in 2004. My biomedical monitoring research group is multidisciplinary, embracing both the development of fundamental physical/ analytical science methods, particularly combining microfluidic devices with electrochemical sensors, and the use of these new techniques in a program of neuroscience and clinical science research. My approach is to combine real-time measurement of neurochemical, electrical and physical measurements such as blood flow and local brain pressure to give a clear picture of the dynamics of tissue response to stimulation or trauma. The same measurement techniques are used in patients and in experimental models allowing genuine translational research.

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Microfluidic Devices for Real-Time Clinical Monitoring of Microdialysis Streams

Thursday, 18 September 2014 at 11:15

Add to Calendar ▼2014-09-18 11:15:002014-09-18 12:15:00Europe/LondonMicrofluidic Devices for Real-Time Clinical Monitoring of Microdialysis StreamsLab-on-a-Chip, Microfluidics and Microarray World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com

Microdialysis probes are an FDA approved way of sampling the molecular composition of human tissue including the brain, the low volume flow rates (0.2 – 2 µL / min) of microdialysis probes are ideal for linking to microfluidic analysis devices. Concentrations of key biomarker molecules can then be determined continuously using either electrochemically (using amperometric, and potentiometic sensors) or optically.  Droplet-based microfluidics, by digitizing the dialysis stream into discrete low volume samples,  (a) allows rapid concentration change to be detected without the effects of the temporal smearing caused by dispersion, and  (b) allows dialysate droplets to be quickly transported from the patient or surgical field to the analysis chip. This talk will describe the design, optimization, calibration and use of both droplet-based and continuous flow microfluidic analysis systems for clinical monitoring during reconstructive surgery and, for traumatic brain injury patients, extended monitoring of the brain in the intensive care unit.


Add to Calendar ▼2014-09-18 00:00:002014-09-19 00:00:00Europe/LondonLab-on-a-Chip, Microfluidics and Microarray World CongressLab-on-a-Chip, Microfluidics and Microarray World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com