Martyn Boutelle,
Professor of Biomedical Sensors Engineering,
Imperial College London
Martyn Boutelle is Professor of Biomedical Sensors Engineering in the Department of Bioengineering, Imperial College London, and Associate Provost for Estates Planning for Imperial College. His research group is multidisciplinary comprising, bioengineers, scientists, and clinicians. He develops novel analytical science methods using microfluidics, electrochemical sensors / biosensors, and wireless electronics to make portable (sometimes wearable) monitoring devices for use as point of care devices that typically giving continuous real -time displays. He then uses these in a program of clinical science research focusing on the acute traumatic brain injury including that caused by cardiac arrest, neonatal continuous monitoring and kidney transplantation monitoring. He runs the EPSRC funded Bio-nanofabrication suite designed to make microfluidic and biosensor biosensors using scalable methods to allow use in proof-of-concept clinical trials.
Martyn is past president of the International Society for Monitoring Molecules in Neuroscience, and a founder of the COSBID organization for studying acute human brain injury. He published > 190 papers, chapters and patents. He obtained a BSc and PhD in Chemistry from Imperial College and worked as an EP Abraham Research Fellow in the University of Oxford.
Microfluidic Devices for Real-Time Clinical Monitoring of Microdialysis Streams
Thursday, 18 September 2014 at 11:15
Add to Calendar ▼2014-09-18 11:15:002014-09-18 12:15:00Europe/LondonMicrofluidic Devices for Real-Time Clinical Monitoring of Microdialysis StreamsLab-on-a-Chip, Microfluidics and Microarray World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Microdialysis probes are an FDA approved way of sampling the molecular composition of human tissue including the brain, the low volume flow rates (0.2 – 2 µL / min) of microdialysis probes are ideal for linking to microfluidic analysis devices. Concentrations of key biomarker molecules can then be determined continuously using either electrochemically (using amperometric, and potentiometic sensors) or optically. Droplet-based microfluidics, by digitizing the dialysis stream into discrete low volume samples, (a) allows rapid concentration change to be detected without the effects of the temporal smearing caused by dispersion, and (b) allows dialysate droplets to be quickly transported from the patient or surgical field to the analysis chip. This talk will describe the design, optimization, calibration and use of both droplet-based and continuous flow microfluidic analysis systems for clinical monitoring during reconstructive surgery and, for traumatic brain injury patients, extended monitoring of the brain in the intensive care unit.
Add to Calendar ▼2014-09-18 00:00:002014-09-19 00:00:00Europe/LondonLab-on-a-Chip, Microfluidics and Microarray World CongressLab-on-a-Chip, Microfluidics and Microarray World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com