Danilo Tagle,
Director, Office of Special Initiatives,
National Center for Advancing Translational Sciences at the NIH (NCATS)
Dan Tagle is Director of the Office of Special Initiatives at NCATS where he many coordinates efforts towards development of disruptive technologies in translational research. He obtained his Ph.D. in Molecular Biology and Genetics from Wayne State University School of Medicine. He was an NIH National Research Service Award postdoctoral fellow in Human Genetics at the University of Michigan. He has served on numerous committees, advisory boards, and editorial boards. He has authored many scientific publications and has garnered numerous awards, including more recently the Roscoe O. Brady Award for Innovation and Accomplishment, and the Henry J. Heimlich Award for Innovative Medicine.
Human Microphysiological Systems: Organs-on-Chips for In Vitro Efficacy, Safety, and Toxicity Testing
Wednesday, 30 September 2015 at 08:00
Add to Calendar ▼2015-09-30 08:00:002015-09-30 09:00:00Europe/LondonHuman Microphysiological Systems: Organs-on-Chips for In Vitro Efficacy, Safety, and Toxicity TestingLab-on-a-Chip, Microfluidics and Microarrays World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Advances in basic and preclinical science continue to fuel the drug discovery pipeline, however only a small fraction of compounds meet criteria for approval by the US FDA. More than 30% of promising medications have failed in human clinical trials because they are determined to be toxic despite promising pre-clinical studies in animal models, and another 60% fail due to lack of efficacy. The challenge of accurately predicting drug toxicities and efficacies is in part due to inherent species differences in drug metabolizing enzyme activities and cell-type specific sensitivities to toxicants. To address this challenge in drug development and regulatory science, the US NIH has invested 75 million dollars over a 5-year period to launch in 2012 the Microphysiological Systems (MPS) or Organs-on-Chips Program to develop alternative approaches that would enable early indications and potentially more reliable readouts of toxicity or efficacy.
Add to Calendar ▼2015-09-28 00:00:002015-09-30 00:00:00Europe/LondonLab-on-a-Chip, Microfluidics and Microarrays World CongressLab-on-a-Chip, Microfluidics and Microarrays World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2015-09-30 08:00:002015-09-30 09:00:00Europe/LondonHuman Microphysiological Systems: Organs-on-Chips for In Vitro Efficacy, Safety, and Toxicity TestingLab-on-a-Chip, Microfluidics and Microarrays World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
