Paul Bohn,
Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering and Professor of Chemistry and Biochemistry,
University of Notre Dame
Paul W. Bohn received the B.S. from the University of Notre Dame in 1977 and the Ph.D. from the University of Wisconsin-Madison in 1981, both in Chemistry. After two years at Bell Laboratories, he joined the faculty at the University of Illinois at Urbana-Champaign (UIUC). In 2006, he moved to the University of Notre Dame where he is currently the Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering, Professor of Chemistry and Biochemistry, and Director of the Institute for Precision Health. He served as Editor for the Americas for the RSC journal Analyst 2007-09 and as Chair of the Editorial Board 2010-14. Prof. Bohn is currently co-editor of Annual Review of Analytical Chemistry. His research interests include: (a) integrated nanofluidic and microfluidic chemical measurement strategies for personal monitoring, (b) chemical and biochemical sensing in mass-limited samples, (c) biochemical imaging, and (d) molecular approaches to nanotechnology, areas in which he has over 290 publications and 10 patents.
Integrated Microfluidics for Vectorial Coupling of Sequential Chemical Reactions in Nanopores and Nanochannels
Tuesday, 29 September 2015 at 15:30
Add to Calendar ▼2015-09-29 15:30:002015-09-29 16:30:00Europe/LondonIntegrated Microfluidics for Vectorial Coupling of Sequential Chemical Reactions in Nanopores and NanochannelsLab-on-a-Chip, Microfluidics and Microarrays World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
A defining characteristic of microfluidic processing is that rectilinear fluid flow converts time and space variables, enabling the adjacent placement of reaction zones in nanopores to achieve vectorial coupling of sequential chemical transformations. We are investigating how nano-architectures can be incorporated into microfluidic lab-on-a-chip devices so that molecular transport can be used to couple analyte/reagent generation with its subsequent downstream use. In this context electrons constitute a particularly interesting and powerful chemical reagent, and microfluidic architectures present numerous novel schemes to couple electron transfer and electron transport. For example, bipolar electrodes can be used to connect distinct fluidic channels, allowing disparate redox processes to be coupled. In these experiments self-induced redox cycling can be used (1) to amplify the sensitivity of amperometric measurements, and (2) to couple the electron transfer event to a luminescence readout using, for example, electrogenerated chemiluminescence. Thus, the chemical detection event (current) is spatially and temporally separated from the readout event (photons). Alternatively the downstream electrode can be used for chemical processing, allowing product to be generated only when an enabling “signal” species is present. All of these processes depend on a detailed quantitative understanding of the coupling of electrochemical transformations to fluid flow. Semi-quantitative estimates of generation/consumption dynamics obtained from finite element modeling can then be compared to quantitative nanoscale experiments.
Add to Calendar ▼2015-09-28 00:00:002015-09-30 00:00:00Europe/LondonLab-on-a-Chip, Microfluidics and Microarrays World CongressLab-on-a-Chip, Microfluidics and Microarrays World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2015-09-29 15:30:002015-09-29 16:30:00Europe/LondonIntegrated Microfluidics for Vectorial Coupling of Sequential Chemical Reactions in Nanopores and NanochannelsLab-on-a-Chip, Microfluidics and Microarrays World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
