Noo Li Jeon is a Professor of School of Mechanical and Aerospace Engineering at Seoul National University (SNU). He studied Materials Science and Engineering at Northwestern University (B.S.) and University of Illinois Urbana-Champagne (Ph.D.). He worked on soft lithography applications in Prof G.M. Whitesides’ laboratory at Harvard University and at Prof M. Toner’s group at Harvard Medical School. He was an Associate Professor at UC Irvine from 2001-2009 in the Department of Biomedical Engineering. In 2009, he moved to Seoul National University to join School of Mechanical Engineering at Seoul National University.
Engineering Perfusable Vessel Network in Microfluidic Device for Organ-on-a-Chip Application
Wednesday, 30 September 2015 at 11:00
Add to Calendar ▼2015-09-30 11:00:002015-09-30 12:00:00Europe/LondonEngineering Perfusable Vessel Network in Microfluidic Device for Organ-on-a-Chip ApplicationLab-on-a-Chip, Microfluidics and Microarrays World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
This presentation will describe a reproducible, in vitro approach to form perfusable 3D microvascular networks on a microfluidic chip. The vessels can be formed by angiogenesis or vasculogenesis. These engineered blood and lymphatic vessels exhibit morphological and biochemical markers of tight junctions, apical-basal polarity, basement membrane deposition, and up-regulated markers in response to inflammatory cues. A novel microfluidic device was designed and tested for real-time imaging of various steps of cancer metastasis and immune cell transmigration. Perfusable microvascular networks formed within the microfluidic device reproduce the 3D cellular niche, facilitating high-resolution live imaging of cancer cell extravasation and immune cell intra/extravasation. This approach provides a platform for developing physiologically complex but experimentally straightforward human disease models and holds potential for medical and pharmaceutical applications in drug screening and basic cancer biology and immunology.
Add to Calendar ▼2015-09-28 00:00:002015-09-30 00:00:00Europe/LondonLab-on-a-Chip, Microfluidics and Microarrays World CongressLab-on-a-Chip, Microfluidics and Microarrays World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2015-09-30 11:00:002015-09-30 12:00:00Europe/LondonEngineering Perfusable Vessel Network in Microfluidic Device for Organ-on-a-Chip ApplicationLab-on-a-Chip, Microfluidics and Microarrays World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
