Fanny d'Orlyé's Biography

Fanny d'Orlyé, Associate Professor, Chimie ParisTech, Unité de Technologies Chimiques et Biologiques pour la Santé

Fanny d’Orlyé is an Associate Professor at Chimie ParisTech, Paris, France. After obtaining her PhD in Analytical Chemistry at Pierre and Marie Curie University in 2008, she spent two years at the French Alternative Energies and Atomic Energy Commission (CEA) in Saclay, France, as a post-doctoral fellow. There she was involved in an environmental program initiated in December 2008 by the French Ministry for Ecology, Energy, Sustainable Development and Regional Planning (MEEDDAT) to mobilize large-scale resources and skills in order to decontaminate aquatic habitats polluted by PCBs. In September 2011 she commenced her current position at Chimie ParisTech. Developping capillary electrokinetic separation methodologies and miniaturized chemical analysis systems, she investigates the properties, behavior and fate of new selective agents (such as conjugated nanoparticles, aptamers, …) in biological media and their role as ligands for integrated microextraction methodologies with the goal to develop novel diagnostic approaches either in vivo (probes for imaging) or ex vivo (lab-on-a-chip platforms).

Surface Functionalization Strategies for the Design of Thermoplastic Microfluidic Devices for New Analytical Diagnostics

Wednesday, 28 September 2016 at 16:30

Add to Calendar ▼2016-09-28 16:30:002016-09-28 17:30:00Europe/LondonSurface Functionalization Strategies for the Design of Thermoplastic Microfluidic Devices for New Analytical DiagnosticsSELECTBIOenquiries@selectbiosciences.com

Cyclic olefin copolymer (COC) and fluoropolymer (Dyneon THV) are emerging materials attractive for the conception of microfluidic chips thanks to their UV-visible transparency and high resistance to aggressive solvents. We propose to develop new analytical microsystems using these polymers for trace quantitation in complex matrices. This involves the immobilization of selective ligands in a confined zone of the microchannel for target extraction and preconcentration. This integrated pretreatment step will be followed inside the microdevice by electrokinetic separation and on-line detection. This requires new surface treatments for chemically inert COC and Dyneon to modify the microfluidic system at two scales: (1) on the entire surface to control surface properties and fluid flows during electrokinetic separation, or (2) locally to immobilize selective ligands (aptamers) on restricted areas for target extraction. For global modification, a plasma-induced immobilization of brominated derivatives allowed further ligand immobilization through alkyne-azide “click” chemistry reaction. For local ligand immobilization, we developed an original electrochemical strategy on Dyneon THV microchannel. Local electrochemical carbonization followed by covalent linkage of ligands (aptamers) through “click” reaction leads to immobilization zones in the 50 micrometer range.

Add to Calendar ▼2016-09-26 00:00:002016-09-28 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics: Companies, Technologies and CommercializationSELECTBIOenquiries@selectbiosciences.com

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