Myung-Suk Chun's Biography

Myung-Suk Chun, Leader, Complex Fluids Research Team, Korea Institute of Science and Technology (KIST)

Dr. Myung-Suk Chun is currently leading the Complex Fluids Research Team at the KIST, Seoul. He received BS (1987) degree in chemical engineering from the Seoul National University, and MS (1990) and PhD (1994) degrees from the KAIST. He worked as a postdoctoral associate at the University of California at Davis in 1995–1996 and visited the Max-Planck Institute at Mainz as a DFG-Fellow in 1999. He served as the Editor-in-Chief of the Korea-Australia Rheology Journal (Springer Pub.) from 2012 to 2016 and the Chair of Transport Phenomena Division of the KIChE. Since joining the KIST in 1996, his areas have been including electrokinetic microfluidics, dynamics of soft matter, rheology in confined spaces, and applications to lab-on-chips platform, closely related to either computations or experiments or both.

Highly Efficient Sorting of Adult Stem Cells by Optimally Designed Microfluidic Chip Filtration Coupled with Dean Flow-aided Focusing

Tuesday, 2 October 2018 at 15:00

Add to Calendar ▼2018-10-02 15:00:002018-10-02 16:00:00Europe/LondonHighly Efficient Sorting of Adult Stem Cells by Optimally Designed Microfluidic Chip Filtration Coupled with Dean Flow-aided FocusingSELECTBIOenquiries@selectbiosciences.com

Sorting out a specific human bone marrow-derived mesenchymal stem cell (hMSC) subpopulation with high self-renewal and multipotent capacities is a useful approach to enhance effectiveness of cell therapy. As the continuous sorting into three subpopulations, our group performed flow-based sorting of hMSCs by using optimally designed microfluidic chips based on the hydrodynamic filtration (HDF) principle. In this study, to further improve sorting efficiency and throughput, a spiral channel in the upper layer designed for inertial focusing by Dean flow was coupled with the lower HDF layer. In order to quantify the hMSCs’ sorting efficiency, three subpopulations were set: rapidly self-renewing (RS) (< 23 micrometer), spindle-shaped (SS), and flattened (FL) (> 35 micrometer) cells. Recovery and purity over 91% were achieved higher than those of our previous results. The results of adipogenic and osteogenic differentiations also demonstrated a successful fractionation of three subpopulations. It should be noted that RS and SS subpopulations showed higher self-renewal and multipotent capacities than those of FL one.

Add to Calendar ▼2018-10-01 00:00:002018-10-03 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics: Emerging Themes, Technologies and Applications "Track A"SELECTBIOenquiries@selectbiosciences.com

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