Glucose Deprivation Drives Adaptation Towards Lactate Utilisation and Sensitises Tumour Cells to the First-in-class Monocarboxylate Transporter 1 (MCT1) Inhibitor AZD3965Thursday, 11 September 2014 at 14:15  Add to Calendar ▼2014-09-11 14:15:002014-09-11 15:15:00Europe/LondonGlucose Deprivation Drives Adaptation Towards Lactate Utilisation and Sensitises Tumour Cells to the First-in-class Monocarboxylate Transporter 1 (MCT1) Inhibitor AZD3965Metabomeeting 2014 in London, UKLondon, UKSELECTBIOenquiries@selectbiosciences.comTumour cells frequently experience glucose deprivation together with high lactate exposure. Under these conditions lactate imported through MCT1 represents a vital alternative carbon source. Combining molecular biology and metabolomic techniques we show that tumours cells readily adapt to the metabolic environment to utilise lactate for both energy production and anabolism. This creates a specific opportunity for anti-cancer combination therapy involving specific MCT1 inhibitors. |
Add to Calendar ▼2014-09-10 00:00:002014-09-12 00:00:00Europe/LondonMetabomeeting 2014Metabomeeting 2014 in London, UKLondon, UKSELECTBIOenquiries@selectbiosciences.com
