Maiwenn Kersaudy-Kerhoas,
Professor of Microfluidic Engineering,
Heriot-Watt University
Maïwenn Kersaudy-Kerhoas is a Professor of Microfluidic Engineering at Heriot-Watt University in Edinburgh, Scotland. She leads a multi-disciplinary research group of biologists and engineers. Her work has focused on the development of robust, reproducible and affordable prototyping methods for point-of-care diagnostics. She has developed several pre-analytical tools for liquid biopsies applications with clinicians, including blood plasma separation devices, cell-free DNA extraction cartridges and a finger-actuated blood processing device. In 2013, she received a five year Royal Academy of Engineering Fellowship and in 2018 a Healthcare Technology Challenge Award from the UK Engineering and Physical Science Council. In 2019 she was awarded a Royal Academy of Engineering ‘Frontiers of Development’ and Global Challenge Research Fund seed funding to develop an advanced sepsis diagnostic tool via cell-free microbial nucleic sequencing with clinical partners around the world. She is a recipient of the 2023 Royal Academy of Engineering Frontiers Champion award, which she will use for the creation of a Frugal Diagnostic network.
Near-Patient, Automated Platform for Rapid Microfluidic Extraction of Circulating Nucleic Acids from Milliliter Volumes of Whole Blood
Thursday, 10 October 2019 at 14:00
Add to Calendar ▼2019-10-10 14:00:002019-10-10 15:00:00Europe/LondonNear-Patient, Automated Platform for Rapid Microfluidic Extraction of Circulating Nucleic Acids from Milliliter Volumes of Whole BloodMicrofluidics for Circulating Biomarkers Summit 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Extracellular plasma circulating cell-free nucleic acids (CNAs) are promising clinical biomarkers but their measurement remains time-consuming, technically challenging and expensive. For CNAs to have an impact on healthcare, a key challenge to overcome is the development of rapid and reliable low-cost sample preparation. There is an acknowledged issue around CNAs stability in the presence of hemolysis, and few solutions for fast and robust extraction at the site of blood draw. We demonstrate a microfluidic system able to perform the extraction of circulating miRNAs from several milliliters of whole blood in a single disposable fluidic cartridge, on a fully automated platform, delivering a stable elution of CNAs in less than 45 minutes. The biological characterization of the eluates include qPCR, fluorometric and spectrophotometric analysis, and automated electrophoresis for fragment analysis. This platform enables the standardization of sample preparation at the point of blood draw and in resource limited settings and could aid the introduction of CNAs-based assays into routine clinical practice.
Add to Calendar ▼2019-10-10 00:00:002019-10-10 00:00:00Europe/LondonMicrofluidics for Circulating Biomarkers Summit 2019Microfluidics for Circulating Biomarkers Summit 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2019-10-10 14:00:002019-10-10 15:00:00Europe/LondonNear-Patient, Automated Platform for Rapid Microfluidic Extraction of Circulating Nucleic Acids from Milliliter Volumes of Whole BloodMicrofluidics for Circulating Biomarkers Summit 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
