Tran Ngoc Huyen Nguyen,
Postdoctoral Scholar,
University of Washington
Tran N. H. Nguyen received her B.S. in Chemical Biology from the University of California, Berkeley. After completing a Ph.D. in Biomedical Engineering from Purdue University, she moved to Seattle for a postdoc in the Bioengineering Department at the University of Washington. Her research goals focus on developing high-performing point-of-care/implantable biosensors and microfluidic devices that can be applied to cancer and other chronic diseases.
Detection of Cytochrome C from Micro-Dissected Tumors in Microfluidic Arrays using Aptamer-Based Electrochemical Sensors
Friday, 5 May 2023 at 17:00
Add to Calendar ▼2023-05-05 17:00:002023-05-05 18:00:00Europe/LondonDetection of Cytochrome C from Micro-Dissected Tumors in Microfluidic Arrays using Aptamer-Based Electrochemical SensorsInnovations in Microfluidics 2023 in SeattleSeattleSELECTBIOenquiries@selectbiosciences.com
Functional assays on intact tissues can potentially complement and extend genomics-based approaches for precision oncology by capturing key determinants of therapeutic response, such as tissue architecture, tumor heterogeneity, and the tumor microenvironment (TME). The Folch lab has recently developed a platform for drug development and cancer precision therapy based on a multi-well microfluidic device that can selectively treat a large array of regularly sized, cuboidal-shaped microdissected tissues (referred to as “cuboids”). The tissues are never dissociated and retain much of the native TME. However, the present platform only provides fluorescent readouts, which is a semi-quantitative method best suited to be a single-time-point terminal assay or labor-intensive terminal immunostaining analysis. Thus, we seek to develop a novel platform based on aptamer-based electrochemical sensing, which enables the periodic monitoring of cytochrome c, a cell death indicator. Using the platform, we demonstrate the ability to measure cytochrome c from live cuboids cultured with different drug conditions on our platform.
Add to Calendar ▼2023-05-04 00:00:002023-05-05 00:00:00Europe/LondonInnovations in Microfluidics 2023Innovations in Microfluidics 2023 in SeattleSeattleSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2023-05-05 17:00:002023-05-05 18:00:00Europe/LondonDetection of Cytochrome C from Micro-Dissected Tumors in Microfluidic Arrays using Aptamer-Based Electrochemical SensorsInnovations in Microfluidics 2023 in SeattleSeattleSELECTBIOenquiries@selectbiosciences.com
